Journal article
UKPDS Outcomes Model 2: A new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year united kingdom prospective diabetes Study: UKPDS 82
AJ Hayes, J Leal, AM Gray, RR Holman, PM Clarke
Diabetologia | Published : 2013
Abstract
Aims/hypothesis: The aim of this project was to build a new version of the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS-OM1), a patient-level simulation tool for predicting lifetime health outcomes of people with type 2 diabetes mellitus. Methods: Data from 5,102 UKPDS patients from the 20 year trial and the 4,031 survivors entering the 10 year post-trial monitoring period were used to derive parametric proportional hazards models predicting absolute risk of diabetes complications and death. We re-estimated the seven original event equations and estimated new equations for diabetic ulcer and some second events. The additional data permitted inclusion of new risk fa..
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Awarded by Medical Research Council
Funding Acknowledgements
A. J. Hayes and P. M. Clarke acknowledge the support of Australian National Health and Medical Research Council project grant no. 512463 and capacity building grant no. 571372. A. M. Gray, J. Leal and R. R. Holman acknowledge the support of a UK Medical Research Council project grant on disease modelling (grant ID: 87386). R. R. Holman and A. M. Gray are NIHR senior investigators.